Impulse oscillometry-derived equation for prediction of abnormal FEV1/FVC ratio for COPD screening in Chinese population: a multicenter cross-sectional studyResearch in context

Impulse oscillometry-derived equation for prediction of abnormal FEV1/FVC ratio for COPD screening in Chinese population: a multicenter cross-sectional studyResearch in context

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Summary: Background: The diagnosis of chronic obstructive pulmonary disease (COPD) is based on spirometry that requires a forced expiratory manoeuvre, which is laborious and difficult for mass screening.Impulse oscillometry (IOS) is easier than spirometry and performed with tidal breathing.We sought to develop an equation for predicting forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) and screening vegas golden knights background COPD using IOS parameters.Methods: Data from patients who simultaneously underwent spirometry and IOS were obtained from databases at five tertiary hospitals in China.Multivariable linear regression analysis was used to develop a predictive model for pre-bronchodilator (BD) FEV1/FVC.

Model performance was analyzed against spirometric read more criteria of airflow obstruction (AO, defined as pre-BD FEV1/FVC 0.73: unlikely COPD.The sensitivity and specificity for detecting spirometry-defined COPD were 88.0% and 77.0%, respectively, while the negative predictive value ranged from 93.

7% to 98.6% and positive predictive value ranged from 26.5% to 62.1% across different COPD prevalence groups in the Chinese population.Interpretation: This equation could be useful to screen for COPD particularly in community and primary care settings.

Funding: The Financial Budgeting Project of Beijing Institute of Respiratory Medicine.